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KMID : 0379520190350040361
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한국독성학회지
2019 Volume.35 No. 4 p.361 ~ p.369
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1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis
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Jin Meiying
Hong Young-Eun
Lee Hyun-Ji
Tran Quangdon
Cho Hyeon-Jeong
Kim Min-Hee
Kwon So-Hee
Kang Nak-Heon
Park Ji-Soo
Park Jong-Sun
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Abstract
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1,2-Dichloropropane (1,2-DCP) has been used as an industrial solvent and a chemical intermediate, as well as in soil fumigants. Human exposure may occur during its production and industrial use. The target organs of 1,2-DCP are the eyes, respiratory system, liver, kidneys, central nervous system, and skin. Repeated or prolonged contact may cause skin sensitization. In this study, 1,2-DCP was dissolved in corn oil at 0, 2.73, 5.75, and 8.75 mL/kg. The skin of mice treated with 1,2-DCP was investigated using western blotting, hematoxylin and eosin staining, and immunohistochemistry. 1,2-DCP was applied to the dorsal skin and both ears of C57BL/6J mice. The thickness of ears and the epidermis increased significantly following treatment, and the appearance of blood vessels was observed in the dorsal skin. Additionally, the expression of vascular endothelial growth factor, which is tightly associated with neovascularization, increased significantly. The levels of protein kinase-B (PKB), phosphorylated PKB, mammalian target of rapamycin (mTOR), and phosphorylated mTOR, all of which are key components of the phosphoinositide 3-kinase/PKB/mTOR signaling pathway, were also enhanced. Taken together, 1,2-DCP induced angiogenesis in dermatitis through the PI3K/PKB/mTOR pathway in the skin.
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KEYWORD
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1,2-Dichloropropane, VEGF, Angiogenesis, Skin, NHFD cell
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